Discovery Early Career Researcher Award - Grant ID: DE150101863

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE150101863

Funding Status
Closed

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Funded Activity Summary

Strained alkenes as chemical probes for cysteine sulfenic acid. This project aims to introduce strained alkenes as probes for cysteine sulfenic acid, a poorly understood biomarker for oxidative stress. This probe will enable rapid detection of cysteine sulfenic acid and meet an urgent need for tools to map cysteine redox signalling. Moreover, since many enzymes feature a cysteine sulfenic acid at their active site, the strained alkene probes will also serve as useful inhibitor probes of these enzymes. Such inhibitor probes will provide critical information for potential therapeutic applications in human conditions associated with oxidative stress such as ageing, cancer, and heart disease.

Funded Activity Details

Start Date: 19-01-2015

End Date: 31-12-2017

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $372,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Organic Chemistry | Organic Chemical Synthesis | Analytical Biochemistry

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Analytical Biochemistry | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Organic Chemical Synthesis | Organic Chemistry | Proteins and Peptides

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