Discovery Early Career Researcher Award - Grant ID: DE150101648

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE150101648

Funding Status
Closed

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Funded Activity Summary

A novel mechanism for the control of growth factor activity. Growth factors are secreted signalling molecules that govern fundamental biological processes such as cell growth, proliferation and death. The mechanism for growth factor control by a Membrane Attack Complex/Perforin-like (MACPF) protein is highly novel as MACPF proteins typically function to kill pathogens during the vertebrate immune response. This project aims to reveal how the MACPF protein Torso-like controls highly localised growth factor signalling, using the sophisticated genetic and advanced imaging methods possible in the fruit fly Drosophila. This project aims to understand growth factor control as its deregulation leads to serious developmental disorders and diseases.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2017

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $363,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination) | Receptors and Membrane Biology | Genetics

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Developmental Genetics (incl. Sex Determination) | Expanding Knowledge in the Biological Sciences | Genetics | Receptors and Membrane Biology

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