Discovery Early Career Researcher Award - Grant ID: DE150101243

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE150101243

Funding Status
Closed

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Funded Activity Summary

The molecular mechanisms of dual nucleic acid specificities of SFPQ. Dynamic interactions between proteins and nucleic acids are a fundamental process in gene regulation, where aberrant regulation leads to lethality or various diseases. This project aims to elucidate the underlying mechanisms of DNA-RNA interplay with a multifunctional nuclear protein, splicing factor proline/glutamine-rich (SFPQ) in gene regulation at the molecular level by characterising the interactions between SFPQ and nucleic acids. The results will provide a fundamental understanding of the molecular mechanisms of dual nucleic acid specificities of nuclear proteins in gene regulation, for which no structural information is currently available.

Funded Activity Details

Start Date: 01-05-2015

End Date: 31-01-2019

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $371,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Analytical Biochemistry | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Analytical Biochemistry | Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Structural Biology (incl. Macromolecular Modelling)

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