Discovery Early Career Researcher Award - Grant ID: DE150101196

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE150101196

Funding Status
Closed

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Funded Activity Summary

Elucidation and characterisation of the misfolded protein interactome. Correct expression, folding, and clearance of proteins are critical for all cell functions. However, cell stresses and aging can cause protein balance mechanisms to become overloaded, resulting in the misfolding and aggregation of proteins. Understanding the mechanisms by which protein aggregation occurs and how to prevent the process have become major scientific challenges. This project aims to gain unprecedented insights into the interactors, effectors and fate of misfolded protein aggregates within cells, using new, cutting-edge, catalytic-tagging biochemical tools. Critical interactions will be investigated for their roles in protein aggregation cell death, and in whether modulation of the interaction can also mitigate or reverse the process.

Funded Activity Details

Start Date: 23-03-2015

End Date: 10-11-2016

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $403,536.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Proteins and Peptides | Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in Technology

Other Keywords

Characterisation of Biological Macromolecules | Expanding Knowledge in Technology | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Medicinal and Biomolecular Chemistry | Proteins and Peptides | Proteomics and Intermolecular Interactions (excl. Medical Proteomics)

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