Discovery Early Career Researcher Award - Grant ID: DE140101626

Funded Activity Summary

Flotillin link membrane microdomains to signalling endosome during T cell activation. This project aims to determine the mechanisms that connect signalling microdomains at the cell surface to intracellular signalling endosomes to regulate T cell activation. A T cell immune response begins with the reorganisation of the plasma membrane to yield two-dimensional signalling microdomains that must be connected to the three-dimensional microarchitecture of the endocytic matrix for full T cell activation. This project hypothesises that Flotillin form distinct signalling microdomains in the plasma membrane that internalise to constitute an independent endocytic pathway. Using single-molecule and ultra-fast fluorescence imaging, the project will demonstrate that Flotillin represent a unique two-dimensional to three-dimensional regulatory mechanism for T cell signalling.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-08-2017

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $394,179.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology | Protein Trafficking | Biochemistry and Cell Biology | Receptors and Membrane Biology |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Biochemistry and Cell Biology | Cellular Immunology | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Protein Trafficking | Receptors and Membrane Biology

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