Discovery Early Career Researcher Award - Grant ID: DE140101553

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE140101553

Funding Status
Closed

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Funded Activity Summary

A flexible virus-like particle delivery platform for next-generation vaccines. Murine polyomavirus (MPyV) capsid proteins self-assemble into spherical protein shells approximately 45 nm in diameter. Such virus-like particles (VLPs) are of considerable interest as bionanotechnological tools. The unique flexibility provided by MPyV VLPs will be exploited by exploring the ability of the interior cavity to retain bioactive cargos while engineering novel functionality on the exterior surface by 'mix-and-match' assembly of VLPs from modified components. As a proof of concept for next-generation vaccines that stimulate much needed, broadly protective responses against infectious diseases, model antigens will be delivered to specific immune cells using this nano-container.

Funded Activity Details

Start Date: 01-01-2014

End Date: 25-02-2017

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $395,220.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nanomedicine | Biomaterials | Synthetic Biology | Biomedical Engineering |

ANZSRC Socio-Economic Objective (SEO)

Human Biological Preventatives (e.g. Vaccines) | Expanding Knowledge in Technology

Other Keywords

Biomaterials | Biomedical Engineering | Expanding Knowledge in Technology | Human Biological Preventatives (e.g. Vaccines) | Nanomedicine | Synthetic Biology

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