Discovery Early Career Researcher Award - Grant ID: DE140101268

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE140101268

Funding Status
Closed

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Funded Activity Summary

Stochastic mathematical modelling of the Wnt signalling pathway. The Wnt signalling pathway is pivotal in multicellular organisms, regulating cellular processes such as proliferation, apoptosis and migration. Faulty Wnt signalling is associated with degenerative diseases, developmental disorders and cancers and is therefore a potential target for therapeutic drugs. This project will perform a stochastic spatial simulation of the Wnt signalling pathway which will be matched to experimental data. The model will be extended to integrate with the cell cycle. Increased proliferation in tumours has been linked to mutations in Wnt components. Using the extended model, the effect of Wnt-targeting therapeutic cancer drugs on cancer cell proliferation rates will be predicted and compared to experiments.

Funded Activity Details

Start Date: 26-02-2014

End Date: 01-11-2017

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $386,820.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biological Mathematics | Applied Mathematics | Reaction Kinetics and Dynamics | Signal Transduction |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Mathematical Sciences

Other Keywords

Applied Mathematics | Biological Mathematics | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Mathematical Sciences | Reaction Kinetics and Dynamics | Signal Transduction

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