Discovery Early Career Researcher Award - Grant ID: DE140100199

Funded Activity Summary

Determining the mechanisms of transgenerational epigenetic inheritance. Although previously controversial, there is now little doubt that transgenerational inheritance of epigenetic marks can occur. This phenomenon is difficult to study in humans and many model organisms, in part due to long generation times. To avoid this difficulty, this project will use genetic and molecular biology approaches in the model organism Caenorhabditis. elegans. The project will utilise a robust assay for transgenerational epigenetic inheritance established to identify a collection of genes involved in the process and will determine the interplay between chromatin modifications and small RNA molecules. This project aims to determine the exact epigenetic mark that is transmitted and the mechanisms by which the transmission occurs.

Funded Activity Details

Start Date: 06-01-2014

End Date: 21-03-2018

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $395,220.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics) | Animal Cell and Molecular Biology | Genome Structure and Regulation | Genetics

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Animal Cell and Molecular Biology | Epigenetics (incl. Genome Methylation and Epigenomics) | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Genetics | Genome Structure and Regulation

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