Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0212000
Funding Status
Closed
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Funded Activity Summary
Control of transcription by the cardiac homeodomain protein Nkx2-5. The transcriptional regulatory protein Nkx2-5, a member of the homeodomain superfamily, is essential for heart development and mutations in the human gene cause congenital heart disease. We seek to define the molecular mechanisms that regulate the transcriptional activity of Nkx2-5. We have previously identified a transcriptional activation domain in the C-terminal region that is bipartite in nature and conserved among Nkx2-5 proteins from diverse species. We will characterise the consequences of mutations in this domain in mouse models and search for interacting proteins. Results will advance our understanding of gene regulation in the context of heart disease.Funded Activity Details
Start Date: 2002
End Date: 12-2004
Funding Scheme: Discovery Projects
Funding Amount: $231,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Industrial Biotechnology |
