Discovery Projects - Grant ID: DP0343690

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0343690

Funding Status
Closed

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Funded Activity Summary

Environmental control of genetic/phenotypic interactions in lung development: An evolutionary perspective. Vertebrate lungs all contain morphologically and functionally similar lung lining cells. However, the cellular arrangement (i.e. lung morphology) and the function of the surfactant these cells produce, differs dramatically between species. Hence, a subset of highly conserved lung-specific genes coincides with spectacular phenotypic diversity. How has this diversity evolved? Do environmental conditions, birth strategy or phylogenetic relationships determine lung phenotype? We will experimentally manipulate developing lungs and cells to demonstrate how environmental conditions (temperature, oxygen, lung-fluid regulation and neuro-hormonal input) promote evolutionary processes by altering gene expression, protein/lipid synthesis, cellular differentiation and hence lung morphology/function in animals with different birth strategies.

Funded Activity Details

Start Date: 2003

End Date: 12-2006

Funding Scheme: Discovery Projects

Funding Amount: $300,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Physiology—Systems | Physiology | Ecology And Evolution Not Elsewhere Classified | Animal Physiology—Cell

ANZSRC Socio-Economic Objective (SEO)

Respiratory system and diseases (incl. asthma) | Biological sciences |

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