Discovery Projects - Grant ID: DP200103492

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP200103492

Funding Status
Active

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Funded Activity Summary

Mathematical Modelling of the Mechanobiology of Arterial Plaque Growth. Plaque growth is a chronic inflammatory response induced by the interactions between endothelial cells, lipids, monocytes/macrophages, smooth muscle cells and platelets in the arteries. It involves many different biological processes, such as lipid deposition, inflammation and angiogenesis, and their interactions with the microcirculation. To understand the underlying mechanobiology, we propose to develop a mathematical model to interpret plaque growth by integrating these dynamic biological processes. It will offer a systematic rational understanding of plaque growth. New models will be provided to better interpret biological data and contribute to our knowledge in quantifying complex biological mechanisms during growth and development.

Funded Activity Details

Start Date: 2020

End Date: 12-2024

Funding Scheme: Discovery Projects

Funding Amount: $420,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biological Mathematics | Applied Mathematics | Biomechanical Engineering | Systems Biology

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular System and Diseases | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Mathematical Sciences |

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