Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP190101667
Funding Status
Closed
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Funded Activity Summary
Aquatic chemo-modulators: a novel source for potent molecular probes. This project aims to investigate peptides that modulate prey behaviour. Chemical signalling constitutes much of the language of life underwater. Certain cone snails evolved a hunting strategy, where they release potent peptides to modulate fish behaviour through yet unknown mechanisms. The snail then expands its mouth and eats the fish without resistance. This project will investigate the mechanisms at play using transcriptomics, proteomics, peptide synthesis, behavioural pharmacology and nuclear magnetic resonance. This will advance the knowledge of aquatic chemo-modulators on a functional, structural and evolutionary level, and provide a source of molecular probes with unique pharmacology and applications in human physiology, developmental biology and aquacultures.Funded Activity Details
Start Date: 07-2019
End Date: 12-2022
Funding Scheme: Discovery Projects
Funding Amount: $490,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Proteins and Peptides | Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry | Biologically Active Molecules
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |
