Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP170102220
Funding Status
Closed
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Funded Activity Summary
A bio-enabled synthesis for the glycopeptide antibiotics. This project aims to develop an in vitro biomimetic synthesis for glycopeptide antibiotics (GPAs) by combining peptide synthesis and crosslinking catalysed by biosynthetic Cytochrome P450 enzymes. The crosslinking step in GPA biosynthesis is essential for antibiotic activity but impedes their chemical synthesis. This project will study the in vitro behaviour and characteristics of the biosynthetic P450 enzymes. This will provide direct benefits: the development of new glycopeptide antibiotic derivatives and the identification of new biocatalysts for complex chemical synthesis. Knowledge gained will also directly enable future reengineering of glycopeptide antibiotic production in vivo.Funded Activity Details
Start Date: 2017
End Date: 12-2019
Funding Scheme: Discovery Projects
Funding Amount: $431,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Enzymes | Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry | Organic Chemical Synthesis
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) |
