Linkage Projects - Grant ID: LP0347461

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/LP0347461

Funding Status
Closed

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Funded Activity Summary

Why is the photosynthetic CO2-fixing enzyme, Rubisco, so inefficient? Dissection of the catalytic chemistry by computational simulation and experimental testing. Fixation of CO2 by the enzyme Rubisco during photosynthesis produces organic compounds which feed all life. Despite this critical role, Rubisco catalyses its reaction sluggishly and, worse, discriminates poorly between CO2 and O2, leading to useless products. Our combined expertise equips us to analyse Rubisco's mechanism using quantum-chemical methods and then test predictions experimentally. We will capitalise on our previous successful studies of Rubisco by addressing emergent issues which are the keys to understanding catalytic efficiency and CO2/O2 selectivity: the roles of a carbamylated lysine; the way CO2 addition is rendered irreversible; and the spin inversion inherent in O2 addition.

Funded Activity Details

Start Date: 03-2003

End Date: 12-2005

Funding Scheme: Linkage Projects

Funding Amount: $345,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Theoretical And Computational Chemistry Not Elsewhere Classified | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology |

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Renewable energy | Other

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