Discovery Projects - Grant ID: DP150104515

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP150104515

Funding Status
Closed

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Funded Activity Summary

Bacterial poly-histidine triad proteins. The poly-histidine triad (Pht) proteins are a poorly characterised family of surface proteins expressed by the genus Streptococcus and other Gram-positive genera. Recent studies suggest an important role for Pht proteins in survival of these bacteria in low zinc (Zn) environments. The project hypothesis is that Pht proteins specifically recruit Zn from the extracellular environment and somehow make it available to ATP binding cassette (ABC) transport systems located in the bacterial plasma membrane, beneath the cell wall, facilitating Zn uptake by the bacterium. The aim of this project is to conduct comprehensive molecular characterization of the interactions between Pht proteins, Zn and ABC transporters, and the role of the histidine triad motifs in these interactions.

Funded Activity Details

Start Date: 2015

End Date: 12-2018

Funding Scheme: Discovery Projects

Funding Amount: $384,300.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Microbiology | Bacteriology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |

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