Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP210103885
Funding Status
Active
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Funded Activity Summary
Understanding telomere privilege in pluripotent stem cells. We recently identified that fundamental mechanisms which protect chromosome ends (i.e. “telomeres”) are not conserved between somatic and embryo-derived stem cells. This discovery is without precedent and challenges the dogmatic expectation that cellular functions promoting genome stability are conserved in stem cells. We term the unexpected protective capacity of pluripotent chromosome ends “telomere privilege”. Here we will uncover the molecular, genomic, and proteomic regulators or telomere privilege; determine the breath of telomere privilege in stem cell lineages; elucidate the functional significance of telomere privilege; and exploit telomere privilege to study fundamental biology related to telomeres and the DNA damage response.Funded Activity Details
Start Date: 2021
End Date: 12-2023
Funding Scheme: Discovery Projects
Funding Amount: $555,892.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Developmental Genetics (incl. Sex Determination) | Cell Development, Proliferation and Death | Genetics | Cell and Nuclear Division
