Discovery Projects - Grant ID: DP210103779

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP210103779

Funding Status
Active

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Funded Activity Summary

Unravelling cell wall polysaccharide biosynthesis in pathogenic zygomycetes. This project aims to define mechanisms that control cell wall composition and stability in Rhizopus oryzae, a zygomycete fungus responsible for life-threatening human infections. The biochemical properties and function of vital enzymes involved in a newly discovered cell wall polysaccharide biosynthetic pathway will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology and structural biology. Expected outcomes include new knowledge on the enzymes that synthesise major fucose-based carbohydrates, to guide the future development of novel strategies for antifungal therapies. The data will also be applicable to animal protection from related zygomycete pathogens.

Funded Activity Details

Start Date: 06-2021

End Date: 05-2025

Funding Scheme: Discovery Projects

Funding Amount: $503,315.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Mycology | Medical Infection Agents (incl. Prions) | Biochemistry and Cell Biology |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Infectious Diseases

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