Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP150104754
Funding Status
Closed
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Funded Activity Summary
Tuning Molecular Translocaton by Close-Field Electroporation. This project aims to determine the underlying mechanisms by which DNA and other molecules are able to migrate across the cell membrane in response to highly localised electric fields. It has recently been shown that focusing of electric fields at the cellular level, using an array of small electrodes, results in unexpectedly high cell transfection efficiencies. It has been termed 'close-field electroporation'. Here it is proposed to establish the properties of the electric fields around cells and cell membrane interactions with these fields that enable molecular translocation. This fundamental science could have broad implications in the domains of drug delivery, gene therapy and neural stimulation.Funded Activity Details
Start Date: 02-2015
End Date: 12-2018
Funding Scheme: Discovery Projects
Funding Amount: $384,700.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Biochemistry and Cell Biology | Receptors and Membrane Biology | Nanobiotechnology |
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in Engineering | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in Technology
