Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP140103229
Funding Status
Closed
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Funded Activity Summary
Understanding the mechanism of two important cytochrome P450 catalysed reactions: dehydrogenation and C-C cleavage. Cytochromes P450 are enzymes that play key roles in drug metabolism and biosynthesis. P450s often catalyse hydroxylation but also carry out important transformations such as dehydrogenation or carbon-carbon bond cleavage. Such reactions are pivotal in many biological pathways. This work will elucidate the mechanism of these transformations and the factors that facilitate their occurrence. This will mainly entail the synthesis of small organic mechanistic probes and determining the structure and stereochemistry of the product of enzymic oxidation. Understanding these mechanisms will allow us to predict when such reactions will occur, enabling their utilisation in for example drug design in the avoidance of the formation of toxic metabolites.Funded Activity Details
Start Date: 2014
End Date: 12-2016
Funding Scheme: Discovery Projects
Funding Amount: $330,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Enzymes | Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry | Organic Chemical Synthesis
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Environmentally Sustainable Manufacturing not elsewhere classified |
