Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0881012
Funding Status
Closed
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Funded Activity Summary
A New Model for 3D Migration Involving Claw Structures and Metalloproteinases. This proposal will revolutionize ideas related to cell movement through three-dimensional (3D) matrix. Our method in mimicking the body's dense 3D matrix environment have led to the discovery of a new cell structure called Claws, and the formulation of a new model for 3D invasion in high density matrix. We will study the genes that control this type of migration including those involved in the formation of the cell front (Claw region), the back of the cells and matrix digestion. This work will have significant impact on normal and pathological human conditions from immune responses to tissue regeneration and cancer.Funded Activity Details
Start Date: 03-2008
End Date: 03-2012
Funding Scheme: Discovery Projects
Funding Amount: $240,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Biochemistry and Cell Biology | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall) | Cell Development (Incl. Cell Division And Apoptosis)
ANZSRC Socio-Economic Objective (SEO)
Immune system and allergy | Infectious diseases | Cancer and related disorders |
