Targeting of the APC tumour suppressor to mitochondria: Implications for APC regulation and cellular function

Website
http://purl.org/au-research/grants/nhmrc/512372

Funding Status
Closed

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Funded Activity Summary

Inherited mutations in the APC gene cause colon cancer, and kills 4,700 Australians every year. About 1 in 21 Australians develop colorectal cancer by the age of 75. APC mutations change cells in different ways, triggering the cancer process. We have discovered a new pathway, involving altered movement of APC to mitochondria in tumour cells. This study will investigate how this cancerous change may help our understanding of colon cancer progression.

Funded Activity Details

Start Date: 2008

End Date: 2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $390,116.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

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