Website
https://dataportal.arc.gov.au/NCGP/API/grants/DP210100614
Funding Status
Active
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Funded Activity Summary
Mobile DNA activity in the mammalian primordial germline. Early in pregnancy, a handful of cells in the embryo become primordial germ cells (PGCs). These PGCs will eventually give rise to sperm or egg cells, representing a critical inter-generational genetic link. Mobile DNA sequences target PGCs to create new heritable genetic changes. This proposal aims to analyse the activity, regulation, and consequences of mobile DNA activity in PGCs. This project expects to generate significant knowledge about the origins of mammalian genetic diversity. Expected outcomes include enhanced national and international collaborations across disciplines and new experimental systems. The expected benefit is an enhanced understanding of the mutational processes underlying genetic diversity and disease in mammals.Funded Activity Details
Start Date: 07-2021
End Date: 12-2024
Funding Scheme: Discovery Projects
Funding Amount: $466,508.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Developmental Genetics (incl. Sex Determination) | Animal Developmental and Reproductive Biology | Genomics | Genetics
