Discovery Projects - Grant ID: DP0210630

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0210630

Funding Status
Closed

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Funded Activity Summary

A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.

Funded Activity Details

Start Date: 2002

End Date: 12-2006

Funding Scheme: Discovery Projects

Funding Amount: $180,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression | Protein Targeting And Signal Transduction | Genetics

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

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