Discovery Projects - Grant ID: DP0344072

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0344072

Funding Status
Closed

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Funded Activity Summary

What's bred in bone: effects of thyroid hormone supplementation on bone growth and remodelling in ectotherms and endotherms. Influence of resting metabolic rate (RMR) and exercise activity on bone microstructure is investigated in a variety of amniote taxa. By varying the dose of supplemental triiodothyronine (T3), ectotherms are made hyperthyroid with elevated RMR, and endotherms - hypothyroid with depressed RMR. Effects of T3 are compared against those of mechanical loading, in form of increased daily treadmill exercise. Rates of bone growth and secondary remodelling are determined by histological analysis, and correlated with T3 and bone strain levels. The study tests the hypothesis that evolution of endothermy can be inferred from bone microstructure of fossil bones.

Funded Activity Details

Start Date: 06-2003

End Date: 06-2006

Funding Scheme: Discovery Projects

Funding Amount: $219,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Comparative Physiology | Palaeontology | Physiology | Animal Anatomy And Histology

ANZSRC Socio-Economic Objective (SEO)

Living resources (flora and fauna) | Biological sciences |

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