Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP190101705
Funding Status
Closed
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Funded Activity Summary
Studying early human kidney development using stem cells. This project aims to improve our understanding of cell types, lineage relationships, cell-cell interactions and morphogenetic processes in human kidney development. Investigators have developed a method to produce multicellular kidney organoids from human pluripotent stem cells (hPSC). This project will use gene-edited reporter hPSC lines and high-res imaging to study the lineage relationships and morphogenetic mechanisms of these human kidney organoids. This project aims to validate the origin of nephrons in kidney organoids, study the origin of the renal stroma versus the nephron progenitor, and monitor nephron patterning and segmentation at a clonal level. This will improve our knowledge of human kidney development in a human model.Funded Activity Details
Start Date: 06-2019
End Date: 06-2022
Funding Scheme: Discovery Projects
Funding Amount: $437,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Developmental Genetics (incl. Sex Determination) | Cell Development, Proliferation and Death | Genetics
