Website
http://dataportal.arc.gov.au/NCGP/API/grants/DE170100506
Funding Status
Closed
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Funded Activity Summary
Specialised ribosomes: An unexplored regulatory layer to tune the proteome. This project aims to decipher human ribosome composition across tissues and conditions, and regulate its composition and activity (selective translation of subsets of transcripts) in a tissue-dependent, spatial and temporal manner – a major challenge in biology. Although ribosomes have been historically thought of as uniform entities, recent evidence suggests that their composition might be regulated. Elevating the expression of a target protein without affecting mRNA levels is expected to benefit other disciplines, including biotechnology (e.g. recombinant protein expression), biomedicine (e.g. treatment of a human disease by suppression or enhancement of the levels of key disease-related proteins) and synthetic biology.Funded Activity Details
Start Date: 02-2017
End Date: 08-2018
Funding Scheme: Discovery Early Career Researcher Award
Funding Amount: $372,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Genome Structure and Regulation | Genomics | Systems Biology | Genetics
ANZSRC Socio-Economic Objective (SEO)
Human Biological Preventatives (e.g. Vaccines) | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |
