Discovery Projects - Grant ID: DP0346807

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0346807

Funding Status
Closed

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Funded Activity Summary

Structural and Functional Aspects of the Allosteric Regulation of Pyruvate Carboxylase by Acyl-CoA Compounds. Pyruvate carboxylase occupies a central location in intermediary metabolism catalysing the formation of oxaloacetate, a key component of the Krebs' tricarboxylic acid cycle especially in its synthetic modes in gluconeogenesis, lipogenesis and in the synthesis of neurotransmitters. This project aims: (i) To produce crystals of pyruvate carboxylase for determining its structure by X-ray diffraction; (ii) To use affinity-labelling to determine the amino acid residues in the binding site of the enzyme's allosteric activator, acetyl-CoA; (iii) To construct chimeric enzymes from different species to define regions of the enzyme which affect its responses to its important allosteric activator, acetyl-CoA.

Funded Activity Details

Start Date: 2003

End Date: 12-2005

Funding Scheme: Discovery Projects

Funding Amount: $210,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Genetic Engineering And Enzyme Technology | Biochemistry and Cell Biology |

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Endocrine organs and diseases (incl. diabetes) | Biological sciences

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