Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP150102860
Funding Status
Closed
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Funded Activity Summary
Novel regulation of TRP channels by oxygen-dependent hydroxylation. Factor inhibiting HIF-1 (FIH-1) is an oxygen-sensing asparaginyl hydroxylase. A bioinformatic search identified specific transient receptor potential (TRP) ion channels as likely substrates. The hypothesis is that TRP channels are regulated by hypoxia, mediated through a novel mechanism of oxygen-dependent hydroxylation by FIH. The aim of this project is to investigate how hydroxylation by FIH mediates the hypoxic regulation of TRP channels. Preliminary data show that the first candidate, TRPV3, is activated in hypoxia, is hydroxylated by FIH, and hydroxylation mediates changes in activity. Ion channels are important for the physiological response to hypoxia, and this project aims to define a novel mechanism for this response, with relevance to mammalian physiology.Funded Activity Details
Start Date: 2015
End Date: 08-2019
Funding Scheme: Discovery Projects
Funding Amount: $364,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Enzymes | Cell Physiology | Biochemistry and Cell Biology not elsewhere classified | Medical Physiology |
ANZSRC Socio-Economic Objective (SEO)
Nervous System and Disorders | Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified | Immune System and Allergy
