Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0346844
Funding Status
Closed
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Funded Activity Summary
Total chemical synthesis of a redesigned enzyme, HIV-1 PR, containing an artificial tunable catalytic apparatus. The research project proposed represents a novel approach using total chemical synthesis to study the enzyme action of the HIV-1 PR, an aspartyl protease essential for the replication of AIDS virus. The redesign of the catalytic apparatus will allow us to investigate molecular aspects of its action. The synthetic polypeptide chain will be folded and characterised for the correct folded structure by NMR, and assayed for enzymatic activity. It can be expected that significant new insights into the molecular basis of the properties of the HIV-1 PR will be obtained. This will be an important contribution to biomedical research.Funded Activity Details
Start Date: 2003
End Date: 12-2006
Funding Scheme: Discovery Projects
Funding Amount: $260,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Medicinal and Biomolecular Chemistry | Biological And Medical Chemistry | Organic Chemical Synthesis |
