Discovery Projects - Grant ID: DP240103034

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP240103034

Funding Status
Active

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Funded Activity Summary

The geometry of genome access: lessons from HIV. Access to the cell’s nucleus, and hence its genome, is of deep scientific and commercial significance. It is controlled by a phase-separated diffusion barrier within the nuclear pore complex. Recent evidence, however, has shown that HIV can cross this barrier with its protective capsid intact, despite it being over one thousand times larger than the limit for passive transport. Combining concepts from soft-matter physics with recombinant assays, this project aims to uncover the link between the unique geometry of HIV capsids and their ability to subvert the nucleus’ defenses. The expected outcome is a step-change in the understanding of nuclear access control, with downstream benefits to virology, bio-engineering and bio-technology.

Funded Activity Details

Start Date: 2024

End Date: 12-2026

Funding Scheme: Discovery Projects

Funding Amount: $624,710.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Soft condensed matter | Medical and biological physics | Biological physics | Virology

ANZSRC Socio-Economic Objective (SEO)

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