Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0557390
Funding Status
Closed
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Funded Activity Summary
Functional ubiquitination of neuronal voltage-gated sodium channels. Alterations in the electrical properties of excitable cells occur during tissue injury and regeneration as well as many disease states. Preventing or controlling these changes is a key strategic therapeutic aim. It is, however, only through a comprehensive understanding of the molecular mechanisms that regulate cellular excitability that we can identify these therapeutic targets. The major outcome of this project will be a thorough characterisation of a novel pathway that is potentially crucial in the development, homeostasis and regeneration of the nervous system. Disruption of normal function of this system may underlie the hyperexcitability observed in mannu neurodegenerative conditions.Funded Activity Details
Start Date: 2005
End Date: 12-2008
Funding Scheme: Discovery Projects
Funding Amount: $400,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Cellular Nervous System | Cell Physiology | Biochemistry and Cell Biology | Membrane Biology
