Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP230101031
Funding Status
Active
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Funded Activity Summary
The impact of copper on protein turnover. This project aims to elaborate a novel discovery by the research team, that a conserved copper-binding site in a group of conserved conjugating enzymes promotes ubiquitination of a range of essential proteins leading to their rapid degradation, which might be a means of maintaining copper homeostasis. This project will employ a range of integrated physicochemical, biochemical and cell biology approaches to illuminate the molecular nature of this copper action on the enzyme and its partners. Expected outcomes include an analytical understanding of the molecular mechanisms of this process, and enhanced interdisciplinary collaboration between experts. Potential benefits include new strategies to intervene in copper-related disorders of aging.Funded Activity Details
Start Date: 2023
End Date: 12-2025
Funding Scheme: Discovery Projects
Funding Amount: $597,900.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Bioinorganic chemistry | Characterisation of biological macromolecules | Medicinal and biomolecular chemistry | Structural biology (incl. macromolecular modelling) |
ANZSRC Socio-Economic Objective (SEO)
