Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0664601
Funding Status
Closed
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Funded Activity Summary
Membrane interactions and neurotoxicity of Amyloid Abeta peptides from Alzheimer's disease. A consequence of the increase in human life span is that age-related neurodegenerative diseases such as Alzheimer's disease (AD) are more prevalent. Currently there are limited therapeutic treatments and no cure for AD. The key protein causing AD is Abeta and characterization of the toxic species of this peptide is critical towards identifying potential therapeutic targets. This proposal aims to study mutant peptides made synthetically and to identify a membrane-binding site. By establishing which lipid is critically involved in membrane binding of Abeta and mediating subsequent cell death, drugs may be developed to prevent the binding of Abeta to membranes resulting in neuronal survival and prevention of memory loss in AD patients.Funded Activity Details
Start Date: 2006
End Date: 06-2009
Funding Scheme: Discovery Projects
Funding Amount: $330,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Other Physical Sciences | Biochemistry And Cell Biology Not Elsewhere Classified | Biological And Medical Chemistry | Biophysics
ANZSRC Socio-Economic Objective (SEO)
Health related to ageing | Biological sciences | Chemical sciences |
