ARC Future Fellowships - Grant ID: FT130101767

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/FT130101767

Funding Status
Closed

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Funded Activity Summary

Drugging the undruggable: Development of novel technologies to selectively regulate the expression of targets driving cancer and other diseases. Transcription factors are “undruggable” targets playing a principal role driving cancer. This project will create novel therapeutic strategies to inhibit transcription factors and other elusive targets differentially expressed in diseased cells, without affecting normal tissue. It proposes to construct engineered proteins able to bind and modify specific key genes deregulated in cancer, to correct their expression and stably reprogram the phenotype of the tumour cell in a normal-like state. It outlines the engineering of novel synthetic agents to block specific protein-protein interactions in cancer cells and to induce potent tumour cell death. This work will generate novel and selective therapeutics to treat un-curable forms of tumours.

Funded Activity Details

Start Date: 12-2013

End Date: 12-2018

Funding Scheme: ARC Future Fellowships

Funding Amount: $755,320.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics) | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Medical Genetics (excl. Cancer Genetics) | Genetics

ANZSRC Socio-Economic Objective (SEO)

Cancer and Related Disorders | Expanding Knowledge in the Medical and Health Sciences | Expanding Knowledge in Technology |

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