Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP140102127
Funding Status
Closed
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Funded Activity Summary
Structure and activity determination of membrane-active peptides. Membrane-active peptides, such as antimicrobial and amyloid (Ab) peptides, play an important role in disease. With the growth of antibiotic resistance and increase in Alzheimer’s disease, which is epitomised by plaques of Ab, new drugs are required. Although Ab is toxic in neuronal cell cultures and disrupts cell membranes, the mechanism is unknown. Antimicrobial peptides that target bacterial membranes have evolved as a defence mechanism against infection and, since membranes show little genetic adaptation, could be drug candidates. Model membranes will be developed to elucidate the mechanism of action and key molecular features that determine affinity for membrane lipids of an antimicrobial peptide and full length Ab peptides.Funded Activity Details
Start Date: 2014
End Date: 12-2016
Funding Scheme: Discovery Projects
Funding Amount: $330,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Proteins and Peptides | Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry | Biologically Active Molecules
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |
