Discovery Projects - Grant ID: DP190102543

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP190102543

Funding Status
Active

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Funded Activity Summary

Engineering a chromatin looping factor for artificial gene regulation. This project aims to define mechanisms of chromatin looping and gene activation by a widely expressed mammalian protein. The project will establish if the functions of this protein are modulated by the binding of small molecules, whether it can act in conjunction with closely related proteins, and if post-translational modifications regulate looping and gene activation. Using protein engineering the project will develop synthetic looping factors that can switch on a wide array of target genes. The project aims to answer fundamental questions about how proteins can establish and maintain physical loops in DNA to modulate gene expression. The project will also develop research tools that might ultimately correct diseases caused by the faulty expression of genes.

Funded Activity Details

Start Date: 2019

End Date: 12-2023

Funding Scheme: Discovery Projects

Funding Amount: $540,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression (incl. Microarray and other genome-wide approaches) | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

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