Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0984815
Funding Status
Closed
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Funded Activity Summary
Membrane-associated structure and the effect of metals on Abeta peptide from Alzheimer's disease. Alzheimer's disease currently affects 5% of Australians over 65, and will triple by year 2050 without an effective therapy. Much research to understand the causes of the disease has focused on the distinctive amyloid deposits found in patients' cerebral tissue. Recent evidence suggests that nerve cell death is actually directly caused by soluble forms of the protein fragments and metals that form these deposits. We will investigate the specific molecular structure of these fragments with metals in relation to vesicles which mimic the nerve cell surface. This information may facilitate future biomedical efforts work to develop therapies, as well as develop general techniques to study similar structural problems.Funded Activity Details
Start Date: 02-2009
End Date: 02-2012
Funding Scheme: Discovery Projects
Funding Amount: $360,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Structural Chemistry | Physical Chemistry (Incl. Structural) | Biophysics | Physical Chemistry Of Macromolecules
ANZSRC Socio-Economic Objective (SEO)
Health related to ageing | Aboriginal and Torres Strait Islander health | Physical sciences |
