Discovery Projects - Grant ID: DP0988153

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0988153

Funding Status
Closed

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Funded Activity Summary

New Insights into the Structure and Function of Pyruvate Carboxylase. Pyruvate carboxylase plays an essential roles in insulin secretion by pancreatic islets and in normal brain function, but excess expression of this enzyme in liver and adipose tissue is associated with diabetes and obesity. Understanding the function of each structural feature in the reaction mechanism of an enzyme is essential to designing safe and effective pharmaceuticals that are required to modulate its activity. This project, which will use cutting edge techniques in an experimental model, seeks to characterise this important enzyme's function so that better treatments can be developed in future for diabetes and obesity.

Funded Activity Details

Start Date: 2009

End Date: 12-2011

Funding Scheme: Discovery Projects

Funding Amount: $110,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Genetic Engineering And Enzyme Technology | Biochemistry and Cell Biology |

ANZSRC Socio-Economic Objective (SEO)

Endocrine organs and diseases (incl. diabetes) | Biological sciences

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