Linkage Projects - Grant ID: LP0230976

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/LP0230976

Funding Status
Closed

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Funded Activity Summary

Identification of nuclear reprogramming factors in oocyte cytoplasm. The mature oocyte contains dominant factors that are capable of erasing tissue specific gene expression profiles of somatic cells. These reprogramming factors would be valuable for dedifferentiation of cells and for nuclear transfer in animal cloning. The research involves determination of reprogramming factors present in active cytoplasm following enucleation of the germinal vesicle, blockage of transcription and translation, and timed cultures. The assays will involve maintenance of reprogramming ability and erasure of somatic gene transcription. By subtractive elimination the function of isolated proteins which are involved in reprogramming will be identified for potential recombinant production.

Funded Activity Details

Start Date: 2002

End Date: 12-2007

Funding Scheme: Linkage Projects

Funding Amount: $67,635.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression | Genetics | Cell Development (Incl. Cell Division And Apoptosis) | Genetic Development (Incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

Dairy cattle | Dairy products |

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