Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP220102832
Funding Status
Active
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Funded Activity Summary
Structural basis of plant immune receptor signaling. Plants detect invading pathogens and trigger immune responses in a process called “effector-triggered immunity”, in which pathogen effector (avirulence) proteins are recognized by plant resistance proteins, typically so-called “plant NLRs”. Ongoing work in the applicants’ laboratories has shown that oligomerization into “resistosomes” and NAD+ (nicotinamide adenine dinucleotide) cleavage play central roles in the process. Building on these data, the project aims to characterize the structures of the signaling molecules resulting from TIR (Toll/interleukin-1 receptor) domain-mediated NAD+ cleavage and the structural architecture of plant NLR resistosomes. This knowledge will support the long-term objective of protecting crops from pathogens.Funded Activity Details
Start Date: 04-2022
End Date: 03-2025
Funding Scheme: Discovery Projects
Funding Amount: $500,253.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Plant Cell and Molecular Biology | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Crop and Pasture Protection (Pests, Diseases and Weeds)
ANZSRC Socio-Economic Objective (SEO)
Control of Plant Pests, Diseases and Exotic Species in Farmland, Arable Cropland and Permanent Cropland Environments | Expanding Knowledge in the Biological Sciences |
