Discovery Projects - Grant ID: DP160103393

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP160103393

Funding Status
Closed

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Funded Activity Summary

Predisposed organic synthesis inspired by the simplicty of nature. The aim of this project is to use the simplicity and efficiency of biosynthesis to inspire the development of new strategies for the synthesis of whole families of related natural products with known antibiotic activity. Natural products with potent antibiotic properties are produced by microorganisms as a means of chemical defence. These complex molecules are biosynthesised from a limited set of simple biosynthetic building blocks via predisposed, complexity generating cascade reactions. The project aims to generate new lead compounds for the advancement of next-generation antibiotics. The synthesis of proposed biosynthetic intermediates would also allow enzymatic studies to help confirm the novel biosynthetic proposals.

Funded Activity Details

Start Date: 2016

End Date: 09-2019

Funding Scheme: Discovery Projects

Funding Amount: $353,500.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Organic Chemistry | Natural Products Chemistry | Organic Chemical Synthesis

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences |

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