Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0452106
Funding Status
Closed
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Funded Activity Summary
Glycerotoxin, a unique tool to investigate the dynamic interactions between N-type Ca2+ channels and the exo-endocytic machinery. Communication between neurons relies on exocytosis, a process in which synaptic vesicles containing a neurotransmitter release their content in the extracellular synaptic cleft. We have recently discovered a unique neurotoxin called glycerotoxin (GLTx), which selectively activates Ca2+ channels (Cav2.2), linked with the exocytic machinery in the Central Nervous System. GLTx provide a new tool to further dissect the role of Cav2.2 in controlling neurotransmitter release. GLTx also greatly facilitates synaptic vesicle recycling, suggesting an unexpected link between Cav2.2 activation and the compensatory endocytic machinery. Our goal is to investigate functional coupling between Cav2.2 and the exo- and endocytic machineries using GLTx.Funded Activity Details
Start Date: 2004
End Date: 12-2006
Funding Scheme: Discovery Projects
Funding Amount: $270,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Central Nervous System | Biochemistry and Cell Biology | Membrane Biology | Cell Neurochemistry
