Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP140103465
Funding Status
Closed
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Funded Activity Summary
Structural studies of a reconstructed primordial antigen receptor. Antigen receptors (B- and T-cell receptor) form the basis of the adaptive immune system of humans and all other modern day vertebrates. These complex receptors are believed to have evolved from an extinct homodimeric (symmetrical) ancestor through a process of gene duplication and diversification. However, any molecular insights had so far remained elusive. Using laboratory evolution and X-ray crystallography this project demonstrates that such a primordial receptor can in principle be reconstructed and characterised. The project proposes to expand this work, which will provide intriguing insights into antigen receptor evolution. The reconstruction of basic recognition modules will also be highly beneficial for biosensor applications.Funded Activity Details
Start Date: 03-2014
End Date: 12-2016
Funding Scheme: Discovery Projects
Funding Amount: $400,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Synthetic Biology
