Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0343833
Funding Status
Closed
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Funded Activity Summary
Membrane structure and lipid interactions of the pore-forming toxin Equinatoxin II by NMR. The structure of Equinatoxin II, a pore-forming protein, will be determined in model cell membranes using solid-state NMR spectroscopy. The relationship of molecular structure to bioactivity and the nature of the pore-forming mechanism of this toxin will be determined. The results will aid in understanding how toxins lyse cells and could lead to the design of improved antibiotic peptides. Currently the structure of membrane proteins are difficult to determine and the newly developed techniques used for the structural determination of this membrane-associated protein will be suitable for studying other membrane proteins and receptors of pharmaceutical importance.Funded Activity Details
Start Date: 2003
End Date: 12-2006
Funding Scheme: Discovery Projects
Funding Amount: $285,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Other Physical Sciences | Medical Biochemistry: Proteins And Peptides | Biological And Medical Chemistry | Biophysics
ANZSRC Socio-Economic Objective (SEO)
Biological sciences | Chemical sciences | Physical sciences |
