Discovery Projects - Grant ID: DP190103694

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP190103694

Funding Status
Closed

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Funded Activity Summary

Seminal fluid interferon-gamma: a potential inhibitor of reproductive success. This project aims to investigate mechanisms by which infection, heat stress and psycho-social stress interfere with fertility by inducing a signalling factor in seminal fluid that suppresses female immune adaptation for pregnancy. Factors in seminal fluid in addition to sperm parameters are known to affect male reproductive success, but these are not well defined. The cytokine interferon-gamma (IFNG) is variably present in seminal plasma of several mammalian species. It was recently discovered that IFNG interferes with the female immune response required for reproductive success. This project will investigate how seminal fluid IFNG alters female immune adaptation for pregnancy. This will define how environmental factors induce seminal fluid IFNG and determine whether inhibitory effects of IFNG can be overcome with pharmacological inhibitors to boost reproductive success.

Funded Activity Details

Start Date: 02-2019

End Date: 02-2022

Funding Scheme: Discovery Projects

Funding Amount: $490,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Reproduction | Conservation and Biodiversity | Biological Adaptation | Animal Production

ANZSRC Socio-Economic Objective (SEO)

Flora, Fauna and Biodiversity of environments not elsewhere classified | Expanding Knowledge in the Biological Sciences | Livestock Raising not elsewhere classified |

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