Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0208502
Funding Status
Closed
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Funded Activity Summary
Recombinant probiotics for prevention of enteric infections in piglets. Shigatoxigenic and enterotoxigenic strains of Escherichia coli cause severe diarrhoeal disease and oedema disease in piglets. The resultant morbidity and mortality is a major cause of financial loss to the pig industry both in Australia and overseas. We have conceived a highly novel approach to prevention of these diseases involving molecular mimicry of host receptors for the E. coli toxins and adhesins on the surface of a harmless bacterium. Oral administration of this agent to piglets has the potential to bind free toxins in the gut and prevent colonization of the intestines by the pathogens, thereby preventing disease.Funded Activity Details
Start Date: 2002
End Date: 12-2004
Funding Scheme: Discovery Projects
Funding Amount: $206,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Veterinary Medicine | Bacteriology | Microbiology
ANZSRC Socio-Economic Objective (SEO)
Pigs | Prevention—biologicals (e.g. vaccines) | Treatments (e.g. chemicals, antibiotics) |
