Discovery Projects - Grant ID: DP0211497

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0211497

Funding Status
Closed

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Funded Activity Summary

Mechanistic basis of a reproductive lesion in transforming growth factor beta-1 (TGFb1) null mutant mice. Null mutation in the gene encoding the cytokine transforming growth factor beta-1 (TGFb1) causes infertility in male and female mice. In recent experiments we have found that TGFb1 deficiency is associated with impaired ovarian and testicular steroidogenesis, arrested development of pre-implantation embryos and disrupted mammary gland morphogenesis. The aims of the current project are to unravel the mechanistic basis of the reproductive lesion in TGFb1 null mutant mice and to determine the effect of exogenous systemic delivery of TGFb1 in alleviating this lesion. It is expected that the project will provide new insight into key roles for TGFb1 in governing male and female fertility, and shed light on the prospects for exogenous supplementation of TGFb1 for improving reproductive performance in wild-type animals. This knowledge has potentially important applications in the livestock breeding industry, in devising novel contraceptive vaccine strategies, in the human pharmaceutical industry, and in devising novel contraceptive vaccine strategies.

Funded Activity Details

Start Date: 2002

End Date: 12-2005

Funding Scheme: Discovery Projects

Funding Amount: $276,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Paediatrics and Reproductive Medicine | Reproduction | Cell Development (Incl. Cell Division And Apoptosis) | Animal Physiology—Cell

ANZSRC Socio-Economic Objective (SEO)

Prevention—biologicals (e.g. vaccines) | Other (incl. production enhancement) | Treatments (e.g. chemicals, antibiotics) |

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