Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP140103965
Funding Status
Closed
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Funded Activity Summary
Genetic control of spermatogenesis: defining the role of SOX3 in spermatogonial progenitor cells. The transcription factor (TF) SOX3 is a key regulator of neural stem/progenitor cells. Recently, this project has also shown that SOX3 is active in sperm progenitors (spermatogonia) and is required for spermatogenesis. Using our Sox3 KO mouse model and extensive expertise in spermatogonial cell culture, ChIP-seq technology and bioinformatics, this project will investigate crucial aspects of SOX3 function in the testes including stem versus progenitor cell activity and genome-wide target gene regulation. These studies will uncover the molecular and cellular mechanism by which SOX3 controls spermatogenesis and provide unique insight into how a single TF controls context-dependent differentiation in sperm versus brain progenitor cells.Funded Activity Details
Start Date: 2014
End Date: 12-2017
Funding Scheme: Discovery Projects
Funding Amount: $390,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Developmental Genetics (incl. Sex Determination) | Gene Expression (incl. Microarray and other genome-wide approaches) | Cell Development, Proliferation and Death | Genetics
ANZSRC Socio-Economic Objective (SEO)
Animal Production and Animal Primary Products not elsewhere classified | Expanding Knowledge in the Biological Sciences |
