Website
https://dataportal.arc.gov.au/NCGP/API/grants/DP160100224
Funding Status
Closed
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Funded Activity Summary
Control of selective microRNA release via exosomes and microvesicles. This project aims to improve our understanding of cell-to-cell communication. Cells release genetic material including microRNAs in lipid membrane-enclosed vesicles (called exosomes and microvesicles) to alter neighbouring and distant cells. Recent research shows that the contents of these vesicles are regulated by cell state, however, the molecular mechanisms are not yet known. This project will investigate the hypothesis that changes in the RNA-binding protein composition of cholesterol-rich membranes mediate the selection of miRNA loaded in the vesicles. This knowledge may increase our understanding of mechanisms of disease because this mode of cell-to-cell communication is disrupted or hijacked in pathologies. Future translation in diverse applications may improve human, animal and plant health.Funded Activity Details
Start Date: 04-2016
End Date: 04-2019
Funding Scheme: Discovery Projects
Funding Amount: $374,500.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Biochemistry and Cell Biology | Receptors and Membrane Biology | Biochemistry and Cell Biology not elsewhere classified
