Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP170100036
Funding Status
Closed
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Funded Activity Summary
Multiplexed bio-imaging mass spectrometry. This project aims to develop technology for simultaneous three-dimensional imaging of trace elements and molecules in biological tissues. This technology is an essential analytical and diagnostic advance to uncover latent mechanistic biology and will reveal subtle metabolic interactions between cells. The project will use laser ablation-inductively coupled plasma-mass spectrometry and lanthanide-conjugated probes to map the zinc metabolic pathway in the ageing mouse brain. It is expected to result in a complete imaging solution for quantitative spatial determination of all important elements, co-factors, metabolites and other functional molecules to investigate metabolic pathways which current technologies find difficult or impossible to track. Ultimately this technology is expected to underpin investigations of diseases where trace metal and chemical species dysfunction is implicated.Funded Activity Details
Start Date: 2017
End Date: 07-2020
Funding Scheme: Discovery Projects
Funding Amount: $416,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Analytical Chemistry | Analytical Biochemistry | Analytical Spectrometry
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Physical Sciences | Expanding Knowledge in the Biological Sciences |
